•
ligand
英：【lɪgənd】美：【lɪgənd】
英：
美：
n.
配合基；向心配合价体
1 、The factors of influencing coordinate polymer structure, such as metal ions and
ligand
, were discussed. The reaction conditions of coordinate polymer were studied.───摘要讨论了影响配合物结构的一些因素；金属离子和配体等。也研究了配位聚合物的反应条件。
2 、The FTRaman spectrum of 4,5diaza9(4,5ethylenedithio1,3dithiol2ylidene)fluorene(DEDYF),a sulfurrich conjugation
ligand
with chelating nitrogen,was studied.───文献名称4,5-二氮-9-【4,5-双(亚乙基硫代)-1,3-二硫杂环戊二烯-2-内翁盐】-芴(DEDYF)的傅里叶-拉曼光谱研究
3 、Abstract The NGR peptide is a
ligand
specifically binding to tumor angiogenic blood vessels, and thus has potential usage in the diagnosis and therapy of tumor.───摘要 天门冬酰胺酰甘氨酰精氨酸(NGR)是特异性地**于肿瘤新生血管受体的多肽基序,在肿瘤诊断和治疗方面具有潜在的应用前景。
4 、SAA
ligand
Lg could catalyze asymmetric addition of phenylacetylene to unactivated aromatic ketones in high yields (up to 83%) and high enantioslectivities (up to 83%ee).───SAA配体Lg用于催化炔基锌对未活化酮的不对称加成反应,对于芳香酮的催化反应,收率可达83%,对映体选择性可达83%ee。
5 、In five patient/donor pairs with AML-M_4 and AML-M_5,6 up-regulated (STAT5B,
ligand
p62 for the Lck SH2,CST3, LTC4S,myeloid leukemia factor 2 and epb72) and 1 down-regulated genes (CCR5) were identified.───5例AML M4和AML M5患者中亦存在 7条显著差异表达基因 ,其中上调表达 6条 (STAT5B ,ligandp6 2fortheLckSH2 ,CST3,LTC4S ,myeloidleukemiafactor 2 ,epb72 ) ,下调表达 1条 (CCR5 )。
6 、CD40-CD40
ligand
interaction induced a robust stimulation of the DAG-PKC pathway and calcium mobilization from intracellular pool in PBMC.───CD40-CD40L相互作用能激活人外周血单核细胞【Ca~(2+)】_i动态变化及二酰基甘油-蛋白激酶C信号通路。
7 、The formation characteristics and conditionsof micellar mixed
ligand
complexes are also reported.───介绍了胶束混配络合物的反应特点和形成条件。
8 、Radiolabelled glucose,amino acid and
ligand
are commonly used as PET tracer in meningioma diagnosis.───PET在脑膜瘤诊断中常用糖类、氨基酸等代谢物类显像剂以及受体类显像剂。
9 、When the complex of anhydrous zinc acetate with 1,5-naphthalene diamine was formed, the anhydrous zinc acetate changed from a bidentate
ligand
to a unidentate
ligand
.───在无水乙酸锌与1,5-萘二胺形成配位络合物的过程中，无水乙酸锌的结构从双齿型转变成单齿型。
10 、The measuring method of the coordination number and the researching achievements of coordination structure on metal complexes with organic
ligand
,especially for polymer compound,are reviewed.───介绍金属离子与有机化合物特别是有机高分子化合物的配位数测定方法和配位结构的主要研究成果。
11 、It is also noticed PD-1
ligand
, PD-L1 expression is abundant on many cancers.───PD-1配体(PD-L1)在许多癌组织中表达丰富，因此，负性共刺激分子对于调控免疫反应是非常重要的。
12 、The effects of the
ligand
structures on the enantioselectivity were also studied.───同时研究了配体的结构对反应的对映选择性的影响。
13 、"Any
ligand
that can Bind to the metal at two or more points to form a ring structure, more stable than a nonchelated compound of the same general chemical formula, is a chelating agent.───任何一个配位体可以在两个或两个以上的点上与金属连结,形成一个环状结构,它比拥有同样化学式的无螯合的化合物稳定,是一种螯合剂。
14 、Its
ligand
is sialyl Louis oligosaccharides or similar molecular structure,and expresses in neutrophils,eosinophils and normal bone marrow precursor cells.───其配体是唾液酸化的路易斯寡糖或类似结构的分子,在中性粒细胞、嗜酸性粒细胞和正常骨髓前体细胞上大量表达。
15 、AAS and EA gave the results that the concentration of CuCl_2 and
ligand
were 1.67mmol/gcat, 1.54mmol/gcat respectively.───原子吸收以及元素分析结果表明,该负载催化剂上CuCl_2含量为1.67mmol/g,配体含量1.54mmol/g,两者以接近1:1 的比例配位;
16 、Methods Expressions of Fas and Fas
ligand
(FasL) were detected in 30 lesions of discoid lupus erythematosus(DLE) and 5 skin specimens from healthy controls by immunohistochemical staining.───方法 采用免疫组化法检测了 30例盘状** (DL E)患者皮损及 5例正常对照皮肤 Fas及 Fas配体 (Fas L )的表达。
17 、This problem may be conveniently resolved by placing an "arm" between the matrix and
ligand
.───在载体与配基之间接上一只“手臂”，这个问题就容易解决了。
18 、Among those factors, organic
ligand
was the most important matter influencing the morphology of DMC complex.───其中有机配体对DMC催化剂形态的影响是最主要的。
19 、Most of proteins firstly combine with
ligand
or form protein complex with other proteins, and then participate in the process of cell metabolism.───其中，多数蛋白质是通过与配体结合或是作为蛋白质复合物中的一部分参与细胞的代谢过程。
20 、Molecu lar docking serves as a method to simulate the interactions of two molecu les (such as
ligand
and receptor) and to predict their binding mode a nd affinity.───分子对接是研究分子间(如配体和受体)相互作用,并预测其结合模式和亲合力的一种理论模拟方法。
21 、The departing halide extracts a proton from the second water and the generated hydroxyl
ligand
reacts with the ethylene, while remaining in the coordination sphere of the metal.───分开的卤化物从第二个水分子得到一个质子，同时产生的羟基配合体与乙烯反应，留在了金属的配位区内。
22 、Agmatine is a novel neurotransmitter and/or neuromodulator, which is the endogenic
ligand
of the imidazoline receptors.───摘要胍丁胺是一种新的神经递质和／或神经调质，是咪唑啉受体的内源性配体。
23 、Because the binding of the neurotransmitter (
ligand
) to the receptor activates these ion channels, they are called
ligand
-gated channels to distinguish them from voltage-gated channels.───因为神经递质和受体结合(配位)启动了这些离子通道,所以他们被称为配位门通道,以区别于电压门通道。
24 、The
ligand
can carry a variety of functionalities, including fluorescent labels, affinity handles and attachments to a solid phase.───可使活细胞或固定细胞成像：配基可通过细胞膜，且共价键稳定，允许对活细胞或固定细胞成像。
25 、Fas and its
ligand
could play a an role in the injury of human glomerular cell.───Fas?FasL系统在Mcs凋亡中起着重要作用。
26 、Two different methods for recycling
ligand
were tried in AD and AA reactions, respectively.───并采用两种不同的方法进行AD和AA反应中配体的回收和重复使用。
27 、Nociceptin/orphanin FQ (N/OFQ) is the endogenous
ligand
of the opioid receptor-like 1 receptor (NOP), the G-protein coupled receptor which shows overall 60% homology with the classical opioid receptors.───孤啡肽(Nociceptin/Orphanin FQ,N/OFQ)是阿片受体样受体(Nociceptin/orphanin FQ receptor,NOP receptor)的内源性配基。
28 、Human CD21/CR2 is also the receptor for the EB viral membrane glycoprotein gp350/gp220 and HIV-1. CD21/CR2 shows various biological characteristics when it binds to
ligand
with its distinct domains.───同时人CD21/CR2也是EB病毒膜表面糖蛋白gp350/gp220、HIV-1等的受体,CD21/CR2以不同的结构域与这些配体结合,表现出多种生物学特性。
29 、The effect of organic
ligand
acidity and the amount of the catalyst on the oxidation reaction was investigated.───本文讨论了配位体种类及催化剂用量对反应的影响。
30 、When we used
ligand
4a in the asymmetric addition of phenylacetylene to aldehydes at room temperature, the highest ee was up to 99%.───当我们用配体4a作为催化剂在对苯乙炔对醛的不对称加成反应中,最高的ee可达99%。
31 、Previous studies showed agmatine, an endogenous I1-imidazoline receptor
ligand
, prevents morphine dependence, but the mechanism remains unclear.───尽管以前研究表明胍丁胺能够抑制吗啡依赖，但其作用机制尚不明确。
32 、Asymmetric allylation of 2-nitrocycloketones was catalyzed by palladium with chiral ferrocenylphosphine
ligand
modified by monoaza crown ethers (A-D).───在用氮杂冠醚改良的手性二茂铁膦与钯的络合物催化下,2-硝基环酮可进行不对称烯丙基化反应。
33 、Affinity chromatography of MBP fusion protein relied on thebinding of
ligand
and
ligand
body, which were not affected by the concentration of MgSO4.───MBP融合蛋白的亲和层析依赖于配体与配基的结合，不受溶液中离子浓度的影响；
34 、Instant
ligand
libraries beat the time-to-market constraint.───实时配位体库打破了时间的市场局限。
35 、FCM can display soundly the characteristic of the receptor
ligand
combination between ASGPR and FITC NGA.───FCM能够良好地揭示FITC NGA同ASGPR之间的受配体结合特性 .
36 、The formation of mixcd
ligand
complex may either obtained through simultaneous formation, stepwice formation or reproportionation.───它的形成可以是一步同时生成或逐步生成,也可以是由单一型络合物混合生成。
37 、Sequence differences in the
ligand
binding domain of PXR serve as the molecular basis for the species difference in CYP3A induction.───化学物通过PXR调节CYP3A的表达可能是影响化学物体内代谢的一条重要途径。
38 、Using hydrophilic
ligand
【3H】NMS and lipophilic
ligand
【3H】QNB, two stages of response of mAChR in CCL137 cells to the prolonged treatment with carbachol (GCh) have been demonstrated.───使用亲水性配基【~3H】NMS和亲脂性、膜通透性配基【~3H】QNB,证实氨甲酰胆碱(CCh)所致CCL137细胞中mAChR的减少,可分为两个不同的阶段。
39 、Pressure Effects on Ligand Binding Kinetics for Hemoproteins.───压力对血红素蛋白配合基键联动力学的影响。
40 、ALCAM belongs to immunoglobulin gene superfamily.It is mainly expressed on leucocyte and thymic epithelial cell and is the
ligand
of CD6 lymphocyte antigen.───ALCAM主要表达在白细胞和胸腺上皮细胞,属于免疫球蛋白基因超家族的成员,是淋巴细胞抗原CD6的配基。
41 、The effects of tridentate
ligand
structure, central atom, co-catalyst and supported on property of catalysts are presented.───摘要介绍了三齿配体结构、中心金属原子、助催化剂、负载化等对催化剂性能的影响；
42 、Probably the new nuclear receptor
ligand
s such as FXR
ligand
will be the next compound.───新的核受体配体很可能成为下一代化合物，如FXR配体。
43 、Typical examples are oxalate and ethylenediamine as bidentate
ligand
s, citrate as a tridentate
ligand
, and ethylenediamine tetraacetate (EDTA) as a hexadentate
ligand
.───典型的例子是草酸和乙二胺为双齿配体，柠檬酸作为一个三齿配体，和乙二胺四乙酸（EDTA）作为六齿配体。
44 、Receptor and
ligand
are transported elsewhere.───受体和配基在别处被传递。
45 、When GABA (the
ligand
) binds to the receptor, the receptor changes its conformation, temporarily opening a channel that admits negatively charged ions into the cell.───当GABA（配位子）与这类受体结合时，受体的构形会发生变化，而将通道短暂开启，让带负电的氯离子进入细胞内。
46 、Adhesive molecule,MHC molecule,Fas and Fas
ligand
expression were found to be increased in sympathetic ophthalmia eyes.───另外 ,局部还存在黏附分子、MHC和fasL等免疫相关分子的表达增加。
47 、The effects of tridentate
ligand
structure, central atom, co catalyst and supported on property of catalysts are presented.───介绍了三齿配体结构、中心金属原子、助催化剂、负载化等对催化剂性能的影响;
48 、In recent years,T cell,its subsets and costimulator may play important role in the process of SLE.The structure of CD137,its
ligand
,its function in SLE are reviewed.───本文就共刺激分子CD137的结构、配体、生物学功能及其在系统性**发生、发展中的作用作一综述。
49 、It is occasionally necessary to use a number system to designate the position of each
ligand
.───有时需要用一种编号系统来标明各配体的位置。
50 、BAFF and APRIL are two novel related members of the TNF
ligand
superfamily.───BAFF和APRIL是新近发现的TNF配体超家族2个关系密切的成员。
51 、The phenyl substitutents on the cyclopentadienyl
ligand
affect catalytic activity, stereoregularity , melting temperature of the polystyrene obtained .───在第三章中，这些新型的茂钛化合物经甲基铝氧烷活化后，催化了苯乙烯聚合。
52 、This paper reviews the application of mixed
ligand
complex, surfactant and ternary heteropoly acid in polarographic analysis.───本文综述了混配络合物、面活性剂、元杂多酸在极谱分析中的应用,揭示了三元络合物在极谱分析中应用的乐观前景。
53 、Some albumin molecules may hae undergone steric modification or
ligand
binding such that the immunoreactie sites hae become obscured.───某些白蛋白分子也许经历了空间修饰或配体结合上的改变以至于其免疫反应位点被湮没。
54 、The chloride
ligand
trans to the coordinated ethylene is displaced by an entering water molecule.───反向配位的乙烯氯离子配体被一个进入的水分子取代。
55 、The mRNA and protein expression levels of TF in PPAR
ligand
treaed cells pretreated with LPS were obviously lower than those of the LPS-only group.───PPAR配体处理组中THP-1细胞TF mRNA水平以及蛋白表达量均较单纯LPS刺激组明显降低。
56 、Tumor necrosis factor-related apoptosis-inducing
ligand
(TRAIL) is a member of the tumor necrosis factor (TNF) superfamily.───TRAIL是肿瘤坏死因子超家族成员,广泛表达于多种组织细胞。
57 、The interaction mechanism between
ligand
and acceptor was revealed in structure.It provides scientific basis for designing higher active compounds.───提出了设计高活性化合物的可能结构要求，并将研究结果用于实际化合物的设计中，取得了初步结果。
58 、Pharmacophore hypothesis(PH) is fundamental to de novo design of peptide
ligand
based on the structure of target protein.───在基于靶蛋白结构的多肽分子设计中，药效假说是从头设计方法的基本前提。
59 、The results indi-cate that increase of basicity and steric hindrance of
ligand
,and selectingsuitable transitional metal may increase selectivity and activity of polymericcatalysts.───实验结果说明,增加配位体的碱性和位阻; 选择合适的过渡金属都能提高催化剂的选择性.
60 、Therefore the separation of amines by the
ligand
adsorption resin can be achieved from nonaqueous media, which can overcome the leaka...───因此,磺酸铜型树脂有望应用于在非水体系中吸附分离或去除某些难溶于水的天然产物如生物碱等物质。
61 、To select peptides that bind lipid A from a phage-displayed peptide library.Peptides were screened from a phage-displayed peptide dodecamer library by using lipid A as a
ligand
.───以脂质A为靶标,筛选噬菌体展示十二肽库,三轮后随机挑取14个噬菌体克隆进行结合活性鉴定,并对5个克隆进行序列分析。
62 、Our results indicated that small G-protein Rac1 could medicate
ligand
induced WPB release in HAEC, and the signal pathway of WPB release might be Rac1-dependent ROS regulating mechanism.───小G蛋白Rac1介导HAEC凝血酶诱导的WPB的释放。 WPB的释放机制是Rac1依赖的ROS调节过程。
63 、Asialofetuin (ASF) is the
ligand
of ASGP receptor residing on liver cell surface, can bind its receptor specifically and be degradateded by liver cell.───去唾液酸胎球蛋白(ASF)是肝细胞ASGP受体的天然配体，能被ASGP受体特异结合并被肝细胞清除，被广泛用于肝脏ASGPR研究。
64 、Whether PPARgamma
ligand
effects on plasma angiotensin II concentration and regular the mRNA expression of ATI-receptor.───明确即AR galnlna配体是否影响外周血浆Angiotensin一n浓度和肾动脉ATlmRNA表达。 实验材料和方法一建立糖尿病动物模型
65 、In the model calculations, we optimized molecular geometry of the parent calixarene
ligand
1 and its complex with H3O+.───在这计算模型里，我们得出杯芳烃配合体1和联合体H3O+最可能的分子几何结构。
66 、The glucocorticoid receptor (GR) in peripheral leukocytes of adult and aged athletes was measured by radio-
ligand
binding assay using 【3H】dexamethasone (Dex) as the
ligand
.───本文以【~3H】地塞米松(Dex)为配体,用放射配体结合测定法研究了成年运动员和老年运动员外周血白细胞糖皮质激素受体(GR)的变化。
67 、The inducible costimulator (ICOS) and its
ligand
GL50 are a couple of the newest member of the CD28/B7 family involved in regulating T cell activation.───ICOS及其配体GL50是最近发现的CD28/B7家族的一对新成员。
68 、The AR protein is composed of four domains,the N-terminal domain(NTD)or transactivation domain,the DNA binding domain(DBD),the flexible hinge region and the
ligand
binding domain(LBD).───AR的配体,雄激素是主要的内源性性类固醇激素,而更多的研究却表明雄激素在鱼类性分化过程中不起作用,AR在此过程中的作用尚不清楚。
69 、Methods 410 consecutive sera,sent for routine ANCA testing from hospitalized patients were screened in an anti-BPI ELISA using lightly purified BPI as solid-phrase
ligand
.───方法应用纯化的BPI抗原,以酶联免疫吸附方法(ELISA)检测410份病人血清抗BPI抗体,免疫印迹法验证部分**血清,分析临床资料。结果47例抗BPI**。
70 、SAA
ligand
Lh could induce asymmetric addition of terminal alkyne to aldehydes without using air-sensitive Ti(O~iPr)4and expensive Zn(OTf)2.with good result of high yield (up to 99%) and good enantioselectivities (up to 84%ee).───将SAA配体Lh应用于在无Ti(O~iPr)_4和Zn(OTf)_2的条件下促进端基炔对醛的不对称加成反应中,反应的收率普遍较高,最高达99%,对映体选择性高达84%ee。
71 、The aim of this article is to review recent devel-opment of CCR7,a newly identified chemokine receptor,and its
ligand
CCL21and CCL19.───全文就新近发现的趋化因子受体CCR7及其配体CCL21和CCL19的研究进展作一综述。
72 、TRAIL(TNF-related apoptosis-inducing
ligand
), identified by Wiley and his colleagues in 1995, is a new member of TNF family.───TRAIL是TNF家族的新成员，其基因是Wiley等于1995年发现的。
73 、Taurine is noted for its physiological and pharmacological actions;however the reports about taurine as a kind of
ligand
with cation forming complexes are scarce.───摘要牛磺酸具有广泛的生理药理作用，但是它作为一种配体与阳离子进行配位的报道却很少。
74 、Methods: The recombinant aden-ovirus vector carrying murine FLT3
ligand
(AdmFL) was constructed, AdmFL and/or ADM were injected into the tumor-bearing mice.───方法:构建携带鼠FL的重组腺病毒载体(AdmFL),单独用其或ADM以及两者联用对实验性肝癌小鼠进行治疗,观察抗肿瘤效果。
75 、We need to further validate the relationship between the newly discovered cholesterol sites and the
ligand
binding sites on these receptors.───我们需要进一步地确认在这些受体中新发现的胆固醇位点和配体位点的关系。”
76 、On one hand, complexes 34-43 are a series of complexes of different dimensions based on L1
ligand
.───一方面，配合物34-43是由L1构筑的一系列具有不同维度的配合物。
77 、Qing-chuan Zhen, Ze-sheng Li, Jing-fa Xiao, et al, Homology modeling and PAPS
ligand
(cofactor) binding study of bovine phenol sulfotransferase. J. Mol. Model. 11 , 97, (2005).───张媛,李泽生,肖景发,孙苗等，乙型肝炎表面抗原片段三维结构的同源模建及其配体的设计，高等学校化学学报.26,102,(2005).
78 、The Fas/Fas
ligand
(FasL) system plays an important role in the transduction of apoptotic signal into the cells.───Fas抗原(APO-1/CD95)与Fas配体(FasL)组成的Fas系统，在将凋亡信号转导入细胞内发挥重要作用。
79 、METHODS: Guinea pig lung membrane was used as experimental materials, 3H LTC 4 as radio
ligand
, FPL 55712 as positive control drug and Gn 3 as test drug.───方法:以豚鼠肺膜为实验材料,采用3HLTC4为放射配体,以FPL55712作**对照药物,Gn3为实验药物,进行药物竞争结合实验。
80 、Ligand 3b gave higher enantioselectivity (up to 96% ee) and chemical yield.───在配体3b催化的苯乙炔对醛的不对称加成反应中,产物的ee达到96%。
执行python脚本时，返回：AttributeError是什么原因？
原因在于： 肯定是在调用此处函数之前，所传递进来的变量，此处的self，由于某种原因，没有获得对应的值，而是空值，所以才出现这样的错误。
解决办法： 自己去一点点反向追踪，找到具体是哪里，没有获得对应的值。然后再具体情况具体解决。具体如下： 电脑常见问题解决
1、无法自动识别硬盘控制器 使用非正版的个别操作系统光盘，在安装系统时，容易出现此错误。原因是非正版光盘自动加载的硬盘控制器驱动不符合电脑自身需要的驱动。这种情况就建议换正版光盘安装操作系统。
2、手动更新错误的驱动程序 windows操作系统正常使用，但手动更新驱动程序把硬盘控制器的驱动程序更新错误，导致此故障。解决方法是进入windows系统高级菜单，选择最后一次的正常配置，即可正常进入系统。
3、bios设置变化后所导致 windows操作系统正常，但是由于某些原因，用户修改了bios设置，导致0x0000007b故障。
gly是二齿配体吗？
gly是二齿配体
配体（ligand，也称为配基）是一个化学名词，表示可和中心原子（金属或类金属）产生键结的原子、分子和离子。一般而言，配体在参与键结时至少会提供一个电子。配体扮演路易斯碱的角色。但在少数情况中配体接受电子，充当路易斯酸。